Drosophila Wing Cells. The human CBFA2T3-GLIS2 fusion protein is a key driver of pediatric acute megakaryoblastic leukemia (AMKL), and confers a poor prognosis. Researchers found a way to express CBFA2T3-GLIS2 (red) in larval Drosophila (fruit fly) wing disc cells, confirming a major role for the BMP signaling pathway. This pathway may provide a target for new therapies. Nuclei (green) and actin filaments (purple) are also shown.
Credit: National Cancer Institute (NCI)